The Biology of glycoproteins

Cover of: The Biology of glycoproteins |

Published by Plenum Press in New York .

Written in English

Read online

Subjects:

  • Glycoproteins -- Physiological effect.,
  • Cell interaction.

Edition Notes

Includes bibliographies and index.

Book details

Statementedited by Raymond J. Ivatt.
ContributionsIvatt, Raymond J.
Classifications
LC ClassificationsQP552.G59 B57 1984
The Physical Object
Paginationxiv, 449 p. :
Number of Pages449
ID Numbers
Open LibraryOL2846218M
ISBN 100306415968
LC Control Number84008321

Download The Biology of glycoproteins

This book is in many ways a sequel to The Biochemistry ojGlycoproteins and Proteoglycans. The enormous recent progress in understanding the biological roles of glycoproteins has prompted the present volume. The reasons for studying glycoproteins have multiplied, and.

The reasons for studying glycoproteins have multiplied, and in the present volume the roles played by glycoproteins are explored in a variety of biological situations. The first two chapters describe molecules involved in cell-substratum and cell-cell interactions in a broad sense, and also focus on recent progress in identifying specific.

Chemical Biology of Glycoproteins This book aims to promote more research for improved understanding of protein glycosylation and its application to commercial : Zhongping Tan.

This book is in many ways a sequel to The Biochemistry ojGlycoproteins and Proteoglycans. The enormous recent progress in understanding the biological roles of glycoproteins. Biology of glycoproteins. New York: Plenum Press, © (OCoLC) Online version: Biology of glycoproteins.

New York: Plenum Press, © (OCoLC) Document Type: Book: All Authors / Contributors: Raymond J Ivatt. This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.

Length: pages Enhanced Manufacturer: Royal Society of Chemistry. About this book Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity.

Chemical Biology of Glycoproteins 1st Edition by Zhongping Tan (Editor), Lai-Xi Wang (Editor) ISBN ISBN Why is ISBN important.

ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. Description Part II of this excellent work covers proteoglycans and mucins and deals with many more examples of glycoprotein function. It also covers glycoproteins from four more species (slime mold.

Furthermore, several examples of chemical biology studies using chemically synthesized homogeneous glycoproteins are briefly reviewed. The concluding section summarizes the accomplishments and current challenges in chemical synthesis of N -glycoproteins, and provides a brief outlook for future directions.

Download options Please wait. Glycoproteins can be produced by supplementing lysates with microsomal fractions, or using extracts of eukaryotes such as insect cells, hybridomas and mammalian cells, although the yields are often poor. These systems give glycosylation patterns native to the host which in the case of insect cells can be modified using endoglycosidases and Cited by: 4.

This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation. book is, I think, better, and cheaper, than the MacMillan 'Dictionary of Life Sciences', but nowhere near as useful, for terms, as de Gruyter's 'Concise Encyclopedia' [Biochem E] although this latter is about four times the price.

E J Wood The Biology of Glycoproteins. Although glycoproteins and proteoglycans have been a subject of re search for many years, it is only during the last five or so years that they have aroused the interest of a very broad cross section of investigators in the biological sciences.

The reason for this expanded interest in these molecules is simple: not only are glycoproteins and proteoglycans ubiq uitous, but many are molecules. A glycoprotein is a type of protein molecule that has had a carbohydrate attached to it. The process either occurs during protein translation or as a posttranslational modification in a process called glycosylation.

The carbohydrate is an oligosaccharide chain (glycan) that is covalently bonded to the polypeptide side chains of the protein. Glycoproteins are accessible to study Glycoproteins occur on cell surfaces and many are actively secreted from cells and are thus relatively accessible to biochemical investigations.

Some glycoproteins are amongst the best characterised of proteins, and biochemistry students will undoubtedly have heard of. The chapters in this book cover topics such as the role of glycosylation on the properties of therapeutic glycoproteins; different analytical methods to characterize glycosylation, from the intact proteins to the glycan level, for both N-linked and O-linked glycoproteins; mass spectrometry imaging methodology for glycosylation analysis in.

Glycoproteins are found in most organisms. Only 8 monosaccharides are associated with the structure of glycoproteins. The oligosaccharide chains of glycoproteins are chemical markers used to tag proteins destined to be used outside the cell.

Oligosaccharide chains are attached to protein through either N- or O-glycosidic bonds. Glycoproteins. Glycoproteins have carbohydrate attached to them — a process called glycosylation.

The attachment is a covalent linkage to. the hydroxyl (-OH) group of the R group of serine or threonine - called "O-linked" in both cases or to; the amino group (-NH 2) in the R group of asparagine - called "N-linked".; The carbohydrate consists of short, usually branched, chains of.

The Glycoconjugates: Mammalian Glycoproteins, Glycolipids, and Proteoglycans Volume IV is a collaboration of different experts in the field of molecular biology on the subject of glycoconjugates.

Glycoproteins play a major role in reproduction since they are located on the surface of sperm. Glycoproteins change the plasma membrane permeability making it easier for the attraction of eggs to the sperm cells.

N-linked Glycoproteins These types of glycoproteins are modified and synthesized inside the membrane organelles of a cell. Glycoproteins and a great selection of related books, Springer, Condition: Fair. This is an ex-library book and may have the usual library/used-book markings book has hardback covers.

In fair condition, suitable as a study copy. THE BIOLOGY OF GLYCOPROTEINS. Ivatt, Raymond J. Glycoproteins have carbohydrate attached to them — a process called glycosylation. The attachment is a covalent linkage to: the hydroxyl (-OH) group of the R group of serine or threonine - called " O-linked " in both cases or to the amino group (-NH 2) in the R group of asparagine - called " N-link.

Estimates vary widely, but a common assessment is that upwards of 50% of eukaryotic proteins are modified by some type of glycan. In Mass Spectrometry of Glycoproteins: Methods and Protocols, expert researchers in the field detail many of the methods that are now commonly used for glycoproteomics.

These methods and techniques include robust. Identify the characteristics and biological functions of the three classes of glycoproteins. Simple glycoproteins Proteoglycans Mucoproteins predominantly carbohydrates and contain glycosaminoglycan often secreted play structural roles predominantly carbohydrates and contain N-acetylgalactosamine predominantly protein serve as lubricants Answer Bank.

Glycoproteins and Glycolipids Lipid and proteins on the cell membrane surface often have short carbohydrate chains protruding out from the cell surface, known as glycolipids and glycoproteins. They form hydrogen bonds with the water molecules surrounding the cell and thus help to stabilize membrane structure.

The LibreTexts libraries are Powered by MindTouch ® and are supported by the Department of Education Open Textbook Pilot Project, the UC Davis Office of the Provost, the UC Davis Library, the California State University Affordable Learning Solutions Program, and Merlot.

We also acknowledge previous National Science Foundation support under grant numbers, and Other articles where Glycoprotein is discussed: blood: Blood cells: These glycoproteins, as well as other CSFs, serve as signals from the tissues to the marrow.

For instance, a decrease in the oxygen content of the blood stimulates the kidney to increase its production of erythropoietin, thus ultimately raising the number of oxygen-carrying red cells.

Identify the characteristics and biological functions of the three classes of glycoproteins. Simple glycoproteins Proteoglycans Mucoproteins often secreted predominantly carbohydrates and contain glycosaminoglycan play structural roles predominantly protein predominantly carbohydrates and contain serve as lubricants N-acetylgalactosamine.

The surface glycoproteins of enveloped viruses play a major role in this process as they drive virus contact with host cell surface receptors and penetration into the cytosol.

As such, viral glycoproteins are critical determinants of host range and tropism. Viral surface glycoproteins are also the primary targets of innate and adaptive immunity. Proteoglycans: a special class of glycoproteins / Jeremiah E. Silbert, Merton Bernfield, Robert Kokenyesi --Nuclear and cytoplasmic glycoproteins / Kenneth D.

Greis, Gerald W. Hart --Carbohydrate units of nervous tissue glycoproteins / Jukka Finne --Glycosyl-phosphatidylinositol anchors: structure, biosynthesis and function / Robert N.

Cole. The cell surface is normally covered with sugars that are bound to lipids or proteins. Surface glycoproteins play critically important roles in many cellular events, including cell–cell communications, cell–matrix interactions, and response to environmental cues.

Aberrant protein glycosylation on the cell surface is often a hallmark of human diseases such as cancer and infectious diseases. Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational process is known as glycosylation.

Secreted extracellular proteins are often glycosylated. In proteins that have segments extending extracellularly, the extracellular segments are. This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal storage diseases, glycobiology of human milk.

Monitoring of Glycoprotein Quality Control System with a Series of Chemically Synthesized Homogeneous Native and Misfolded Glycoproteins. Journal of the American Chemical Society(50), -The study of sugars in biology is known as glycobiology -CD4/CD8: (important for immune cell functions) these transmembrane glycoproteins (cluster of differentiation 4,8) are essential in the activation of T-cells -HIV binds to CD4 molecules, enters these cells.

Glycoprotein definition is - a conjugated protein in which the nonprotein group is a carbohydrate. *Response times vary by subject and question complexity. Median response time is 34 minutes and may be longer for new subjects. Give one example (atomic symbol and name) for each of the following a a main-group (representative) element in General Chemistry - Standalone book (MindTap Course List.

Purification of glycoproteins by selectively capturing the glycan component is commonly done utilizing affinity chromatography. The most common affinity matrices are m-aminophenylboronic acid-agarose for nonspecific binding of saccharides, and immobilized lectins for binding specific carbohydrates.

Glycoprotein definition, any of a group of complex proteins, as mucin, containing a carbohydrate combined with a simple protein. See more. Understanding the molecular biology and pathogenesis of ebolaviruses is important for the development of antiviral therapeutics.

Ebolavirus encodes several forms of glycoproteins (GPs), which have some interesting characteristics, including the transcriptional editing coding strategy and extensive O-glycosylation modification, clustered in the.BIOLOGY Practice Book Your STEP Towards A Brighter Future!

7 becomes the part of plasma membrane. It is antagonistic to endocytosis Q Answer is “ RER ” Explanation: Ribosomes are factories of protein synthesis which are attached to the surface RER.

Proteins synthesized by them are added into the cisternae of endoplasmic reticulum. Cisternae are pinched of in the form of transport.Leading experts present recent advances in the biology of the immune system and address its role in health and disease.

Glycobiology Lectures - Professor Carolyn Bertozzi (Berkeley and Howard Hughes Medical Institute) presents, in these two YouTube lecture videos, her perspectives on Chemical Glycobiology.

Lecture 1 provides an excellent.

40034 views Thursday, November 19, 2020